Antimicrobial Activity of the Essential oil from Seed and oleo-gum-resin Ferula assa foetida against Oral Pathogens
Objectives: Medicinal herbs are a new field that, although old, but its scientific purposes became possible with the advancement of chemistry and pharmacy. The purpose of our study was to evaluate the antimicrobial activity of the essential oil from seed and oleo-gum-resin Ferula assa foetida against oral Pathogens.
Materials and Methods: Gas chromatography-mass spectrometry (GC-MS) was used to determine the chemical composition of Ferula assa-foetida seed and oleo gum resin essential oils. In the next step, the disk diffusion method was recruited to measure the antimicrobial effect of studied essential oils on the following cariogenic bacteria: Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguis, Streptococcus salivarius, and Lactobacillus rhamnosus. Finally, the statistical software was SPSS version 17 to analyze the attained data using ANOVA and Kruskal-Wallis tests.
Results: The GC-MS findings exhibited that the main compounds found in the both essential oil yielded from seed and oleo gum resin was and (Z) -1-propenyl sec-butyl disulfide and (E) -1-propenyl sec-butyl disulfide. Both essential oils had significant antimicrobial activity in all concentrations (P-value <0.05). Both essential oils showed the antibacterial properties similar to chlorhexidine. The growth inhibition zone was significantly dependent on the essential oil concentration in all bacteria (P-value <0.05). Furthermore, the essential oils from Ferula assa-foetida oleo-gum-resin had stronger antibacterial properties compared to Ferula assa-foetida seed, which was statistically significant (P-value <0.05).
Conclusion: our study revealed that essential oil from seed and oleo-gum-resin Ferula assa foetida show antimicrobial effect, more laboratory studies are required to show definite conclusion.