A Model for Induction of Dysplasia in Hamster Mucosal Pouch

  • Sara Pourshahidi Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Elaheh Ghasemzadeh Hoseini Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  • Hooman Ebrahimi Oral Medicine Department, Dental Branch, Islamic Azad University, Tehran, Iran
  • Mojgan Alaeddini Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Shahroo Etemad-Moghadam Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Shiva Shirazian Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Precancerous conditions, 12-dimethylbenz(a)anthracene, Administration, Mucosal


Induction of premalignant lesions in animal models is of high value for research purposes. This study aimed to induce dysplasia in hamster mucosal pouch for investigation of dysplastic lesions using dimethylbenz(a)anthracene. The buccal pouch of 10 hamsters was painted with dimethylbenz(a)anthracene for 10 weeks every other day. At 5 and 10 weeks, they underwent histopathological analysis. Clinically, there was no change until week 7; after which mucosal thickening occurred. Hamsters scarified at 5 weeks and 10 weeks demonstrated mild and moderate dysplasia, respectively. dimethylbenz(a)anthracene is a useful tool for inducing dysplastic lesions in the buccal pouch mucosa of hamsters.


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How to Cite
Pourshahidi S, Ghasemzadeh Hoseini E, Ebrahimi H, Alaeddini M, Etemad-Moghadam S, Shirazian S. A Model for Induction of Dysplasia in Hamster Mucosal Pouch. Front Dent. 16(5):402-406.
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